I have a 20 yr history of chronic bladder infections also. I have even had out patient iv therapy with iv rocephan . Like this 46 yo woman I never really totally feel 100% free of my symptoms. Today I had a cystoscopy and my urologist said I have leukoplakia. He prescribed a 10 day course of cipro 500mg bid. I asked about a biopsy and he said it was not necessary. Now I am reading that perhaps a biopsy should be done. Please advice me. I have no known family history of bladder cancer and have never smoked, however, I am reading in the literature that women with leukoplakia or malokoplakia of bladder have a 42% higher incidence of bladder cancer. That is a big percentage. What should I do?