I have parietal cell antibodies and intrinsic factor antibodies which is a classic diagnosis of autoimmune pernicious anaemia. My blood cells didn't enlarge though I was severely vitamin B12 deficiency (I had masked megaloblastic anaemia). Enlarged blood cells show up with a high MCV (mean cell volume).
Excerpt from ASCIA/RCPA Consensus Guidelines Anti-Intrinsic Factor Antibody Testing...
"If both parietal cell antibody and intrinsic factor antibody are positive-
Immunological evidence of Pernicious Anemia
If both parietal cell antibody and intrinsic factor antibody are negative-
No immunological evidence of Pernicious Anemia
If parietal cell antibody is positive but intrinsic factor antibody is negative-
Gastric Parietal cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). In 20-30% of patients, relatives of patients with PA, autoimmune thyroiditis and a small percentage of healthy persons may be positive and run an increased long term risk of pernicious anemia.
A negative Intrinsic Factor antibody result does not exclude the diagnosis of PA as only 60% of patients with PA will have this antibody."
I have parietal cell antibodies and intrinsic factor antibodies which is a classic diagnosis of autoimmune pernicious anaemia. My blood cells didn't enlarge even with severe vitamin B12 deficiency (I had masked megaloblastic anaemia). Enlarged blood cells show up with a high MCV (mean cell volume).
Excerpt from ASCIA/RCPA Consensus Guidelines Anti-Intrinsic Factor Antibody Testing...
"If both parietal cell antibody and intrinsic factor antibody are positive-
Immunological evidence of Pernicious Anemia
If both parietal cell antibody and intrinsic factor antibody are negative-
No immunological evidence of Pernicious Anemia
If parietal cell antibody is positive but intrinsic factor antibody is negative-
Gastric Parietal cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). In 20-30% of patients, relatives of patients with PA, autoimmune thyroiditis and a small percentage of healthy persons may be positive and run an increased long term risk of pernicious anemia.
A negative Intrinsic Factor antibody result does not exclude the diagnosis of PA as only 60% of patients with PA will have this antibody."
I see a few slightly abnormal, but none "off the chart".