Anti-nuclear antibodies (ANA) occur when cells are damaged or dying and nucleoproteins are released which are seen as foreign by the immune system. This could be symptomatic of other things going on, such as intracellular infections that poison cells and even kill them by initiating programmed cell death. Suppressing the immune system with steriods can alleviate some of the symptoms, but have little consequence on the actual cause of the problem. This has to be looked at more broadly for the primary causes of the clinical problem.
You haven't mentioned other signs/symptoms. This is important as it could pont to other factors.
I am not sure where to recommend she go for help in India, and travel to other countries for medical care can be expensive.
ok doctor...they are currently giving succicort steriod to her...and dr .john matthews in Vellore CMC is treating her....so doctor...as u said about vascultitis...the main problem she has as i mentioned is ANA postive...doctor can u tell me is any permanent cure possible for this..are there any institutes in abroad outside INDIA which can take her case as a reasearch one...doctors also said one thing that her eyeball is not round like normal but it is almond shaped...
waiting for your reply doctor..
yours sincerely
Kumar Dibyesh
The high fever and suspected vasculitis strongly suggest one or more infections are present (infections such as Mycoplasma, Chlamydia, Ehrlichia, etc. often cause vasculitis). Although steroids can reduce the immune effects and inflammatory cytokine responses, such treatment will likely do little to combat the actual cause of the vasculitis. Often these same infections cause pancreatitis or infection of the pancreas, with the resulting large swings in blood sugar levels, as insulin levels go up and down. Blood and marrow transplantation are not the answer, because any transplanted blood or tissue will become infected. The infections should be identified and proper treatment initiated.